Vol 6, No 6 (2015) > Mechanical Engineering >

Review of Surface Modification of Nanoporous Polyethersulfone Membrane as a Dialysis Membrane

Gunawan Setia Prihandana, Tutik Sriani, Muslim Mahardika

 

Abstract:

Nanoporous
polyethersulfone (PES) membrane is widely used as a filtration membrane in
hemodialysis systems. Unfortunately, it has low blood compatibility, and
induces blood clots that adhere to the membrane’s surface during dialysis
treatment. This paper reports on a review of surface modification that is used
to improve the PES membrane’s blood compatibility. The method consists of
applying two coating materials, in the form of parylene and fluorinated
diamond-like carbon (F-DLC) films, onto the membrane’s surface. The parylene
film is deposited on the diffusion layer of the membrane surface using glycerin
liquid, while the F-DLC film is specially coated on the supporting layer of the
membrane. The unique property of parylene, which has the characteristics of
conformal coating, prevents the parylene from being coated on the supporting
layer of the membrane. Conversely, F-DLC film, which is hard, fragile and has a
less conformal coating than parylene, is only meant to be coated on the
supporting layer. Finally, the coated membranes, along with the bare PES
membrane, are compared and investigated under a long-term diffusion test to
assess their permeability and blood compatibility. The experiment results show
that both coating materials have the capacity to improve the membrane’s blood
compatibility in different ways.

Keywords: Fluorinated diamond-like carbon; Hemodialysis; Parylene film; Polyethersulfone membrane

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References


Gu, Y., Miki, N., 2007. A Microfilter Utilizing a Polyethersulfone Porous Membrane with Nanopores. Journal of Micromechanics and Microengineering, Volume 17(11), pp. 2308

Liu, Z., Deng, X., Wang, M., Chen, J., Zhang, A., Gu, Z., Zhao, C., 2009. BSA-modified Polyethersulfone Membrane: Preparation, Characterization and Biocompatibility. Journal of Biomaterials Science, Polymer Edition, Volume 20(3), pp. 377–397

National Institute of Health, 2012. Kidney Failure, Medline Plus

Noh, H.S., Huang, Y., Hesketa, P.J., 2004. Parylene Micromolding, a Rapid and Low-cost Fabrication Method for Parylene Microchannel. Sensors and Actuators B: Chemical, Volume 102(1), pp. 78–85

Pernefri, 2014. 5th Annual Report of Indonesian Renal Registry. Indonesian Society of Nephrology, Indonesia

Prihandana, G.S., Ito, H., Nishinaka, Y., Kanno, Y., Miki, N., 2012. Polyethersulfone Membrane Coated with Nanoporous Parylene for Ultrafiltration. Journal of Microelectromechanical Systems, Volume 21(6), pp. 1288–1290

Prihandana, G.S., Sanada, I., Ito, H., Noborisaka, M., Kanno, Y., Suzuki, T., Miki, N., 2013. Antithrombogenicity of Fluorinated Diamond-like Carbon Films-coated Nanoporous Polyethersulfone (PES) Membrane. Materials, Volume 6(10), pp. 4309–4323

Prihandana, G.S., Ito, H., Tanimura, K., Yagi, H., Hori, Y., Soykan, O., Miki,

N., 2015. Solute Diffusion through Fibrotic Tissue Formed around Protective Cage System for Implantable Devices. Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 103(6), pp. 1180–1187

Saito, T., Hasebe, T., Yohena, S., Matsuoka, Y., Kamijo, A., Takahashi, K., Suzuki, T., 2005. Antithrombogenicity of Fluorinated Diamond-like Carbon Films. Diamond and Related Materials, Volume 14(3), pp. 1116–1119

Suja, A., Anju, R., Anju, V., Neethu, J., Peeyush, P., Saraswathy, R., 2012. Economic Evaluation of End Stage Renal Disease Patients Undergoing Hemodialysis. Journal of Pharmacy & Bio-allied Sciences, Volume 4(2), pp. 107–111