Vol 6, No 7 (2015) > Chemical Engineering >

Mathematical Model Controlled Potassium Chloride Release Systems from Chitosan Microspheres

Yuswan Muharam, Widodo Wahyu Purwanto, Kamarza Mulia, Praswasti PDK Wulan, Ismail Marzuki, Mubarokah N. Dewi



Chitosan can be prepared in the form of
microspheres that serve as a depot for bioactive compounds released in a
controlled way to diseased organs. In this study, a mathematical model of
potassium chloride release from chitosan microspheres was developed. The model
was validated using experimental data. The potassium chloride-loading
percentages of 10.01%, 20.84%, and 20.57% were prepared using a cross-linking
method. The potassium chloride loading was kept constant at about 20% when the
potassium chloride mass in the preparation stage was above 5.024 mg/mL.
Experiments and a model calculation of potassium chloride release from the
microspheres with a loading of 10.01% and 20.57% were performed. In general,
the model reproduces the experimental data. The experiments and the calculation
show that during the same period, microspheres containing more potassium
chloride release a higher percentage of potassium chloride than do microspheres
containing less potassium chloride.

Keywords: Chitosan; Microspheres; Moldeling controlled drug release system; Simulation

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