Vol 6, No 7 (2015) > Chemical Engineering >

Mathematical Model Controlled Potassium Chloride Release Systems from Chitosan Microspheres

Yuswan Muharam, Widodo Wahyu Purwanto, Kamarza Mulia, Praswasti PDK Wulan, Ismail Marzuki, Mubarokah N. Dewi

 

Abstract:

Chitosan can be prepared in the form of
microspheres that serve as a depot for bioactive compounds released in a
controlled way to diseased organs. In this study, a mathematical model of
potassium chloride release from chitosan microspheres was developed. The model
was validated using experimental data. The potassium chloride-loading
percentages of 10.01%, 20.84%, and 20.57% were prepared using a cross-linking
method. The potassium chloride loading was kept constant at about 20% when the
potassium chloride mass in the preparation stage was above 5.024 mg/mL.
Experiments and a model calculation of potassium chloride release from the
microspheres with a loading of 10.01% and 20.57% were performed. In general,
the model reproduces the experimental data. The experiments and the calculation
show that during the same period, microspheres containing more potassium
chloride release a higher percentage of potassium chloride than do microspheres
containing less potassium chloride.

Keywords: Chitosan; Microspheres; Moldeling controlled drug release system; Simulation

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